他达那非的心血管作用

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所属分类:临床药物
摘要

为了确定他达那非对心血管系统的影响,对收到TA的4,000个科目的数据库进行安全评估……

他达那非的心血管作用

摘要

摘要<85 mm Hg after coadministration of sublingual nitroglycerin and 他达那非 5 mg (p <0.001 vs placebo) or 他达那非 10 mg (p <0.01 vs placebo) compared with coadministration with placebo. In patients with chronic stable angina taking doses of isosorbide mononitrate on a long-term basis, the mean maximal change in standing SBP was −23 mm Hg for placebo, −23 mm Hg for 他达那非 5 mg, and −26 mm Hg for 他达那非 10 mg. In a study of older subjects (≥55 years of age) with no overt evidence of CAD, the resulting mean maximal change in standing SBP after coadministration of sublingual nitroglycerin was −25 mm Hg for 他达那非 10 mg, −29 mm Hg for 西地那非 50 mg, and −25 mm Hg for placebo. Cardiac mortality rates in 他达那非 studies are consistent with the expected rate in this male population. Across all studies, the incidence rate of myocardial infarction was low in 他达那非-treated patients (0.43 per 100 patient-years) compared with patients who received placebo (0.6 per 100 patient-years), and the incidence rate was comparable to that observed in the age-standardized male population (0.60 per 100 patient-years). The incidence rate of presumed thrombotic strokes in 他达那非 studies (0.27 per 100 patient-years) is comparable to the expected rate in this patient population. The data presented herein suggest that 他达那非 can be safely used by healthy subjects and by patients with cardiovascular diseases. As with 西地那非, the use of 他达那非 is contraindicated in patients receiving nitrate therapy because of the potential for significant hypotensive effects.

摘要

摘要摘要他达那非在心血管系统上的影响,对数据库进行安全评估> 4,000名受试者接受他达那非in> 60临床药理学,第2期,第3期和开放标签研究。在健康的主题中,他达那非造成的血压变化小,这不被认为是临床相关的。每日施用26周的健康男性受试者或温和勃起功能障碍患者导致血压相似的患者,与安慰剂给药后观察到的患者。在患有冠状动脉疾病(CAD)的患者中,在硝酸盐给药之前给药血压导致小降低。由此产生的平均变化常设收缩量慢性稳定心绞痛患者舌下硝基甘油的共同分配后血压(SBP)为-36mm Hg,用于他达那5mg,-31mm Hg,用于他达非10 mg,A28 mm Hg用于安慰剂。此外,更多的人有一个常设的SBP ☆ Robert A. Kloner,MD,博士,博士,博士,Lilly Icos和Pufizer的顾问和研究员。 Malcolm Mitchell,MBBS,MFPM,是Eli Lilly and Company的员工。杰弗里·埃姆米克,博士,博士,博士,是Eli Lilly and Company的员工。查看全文经济好药,权威渠道,品牌保障。【药道网】药到病除,助力生长:索拉尼布价格

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